https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41994 Wed 30 Aug 2023 15:43:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45194 n = 294, 95–106 years; controls: n = 1105, 55–65 years) by assessing their polygenic risk scores (PRS) based on a genome wide association study (GWAS) threshold of p < 5 x 10⁻⁵. PRS were constructed using GWAS summary data from two exceptional longevity (EL) analyses and eight cardiovascular-related risk factors (lipids) and disease (myocardial infarction, coronary artery disease, stroke) analyses. A higher genetic risk for exceptional longevity (EL) was significantly associated with longevity in our sample (odds ratio (OR) = 1.19–1.20, p = 0.00804 and 0.00758, respectively). Two cardiovascular health PRS were nominally significant with longevity (HDL cholesterol, triglycerides), with higher PRS associated with EL, but these relationships did not survive correction for multiple testing. In conclusion, ELL individuals did not have significantly lower polygenic risk for the majority of the investigated cardiovascular health traits. Future work in larger cohorts is required to further explore the role of cardiovascular-related genetic variants in EL.]]> Wed 26 Oct 2022 14:27:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47703 Wed 25 Jan 2023 10:34:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28071 Wed 23 Feb 2022 16:05:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54898 Wed 20 Mar 2024 13:32:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32467 Wed 19 Jan 2022 15:16:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30657 Wed 17 Nov 2021 16:30:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24759 -11). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = 313). Conditional and joint analysis (COJO) confirmed the association of the chromosomal 17 region with ApoH levels. The set of independent SNPs identified by COJO explained 23% of the variance. The relationships between the top SNPs and cardiovascular/lipid/cognition measures and diabetes were assessed in Sydney MAS, with suggestive results observed for diabetes and cognitive performance. However, replication of these results in the smaller OATS cohort was not found. This work provides impetus for future research to better understand the contribution of genetics to ApoH levels and its possible impacts on health.]]> Wed 15 Dec 2021 16:09:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37079 Wed 15 Dec 2021 16:07:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47126 Wed 14 Dec 2022 14:45:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47086 0.05). Similar results were found for IBS subtypes. Higher serum L-arginine concentration had the strongest association with IBS diagnosis, with an odds ratio of 9.03 for those with serum L-arginine at the 75th (84 μmol/L) versus 25th (46 μmol/L) percentile (95% CI: 5.99–13.62). L-arginine had the best discriminative ability with a bias-adjusted area under the receiver operator characteristic curve of 0.859. Conclusions: Higher serum concentrations of L-arginine and endogenous methylarginines are strongly associated with IBS in adults.]]> Wed 14 Dec 2022 09:23:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50277 90% of clinicians would continue specialist follow-up for at least 5 years. The majority of clinicians felt that patients experienced disproportionate fear of recurrence and were reassured by follow-up. After multivariable analysis, clinicians who participated in multidisciplinary teams (MDTs) were more likely to choose de-escalated care for both initial treatment (p = .005) and follow-up care (>5 years, p = .05). Conclusion: Clinician attitudes captured by this survey reflect recent changes in guidelines towards hemithyroidectomy for low-risk WDTC, particularly amongst MDT attendees. There is a need to further examine the impact of de-escalated care on fear of recurrence and quality of life in thyroid cancer survivors.]]> Wed 12 Jul 2023 16:24:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36123 Wed 12 Feb 2020 15:26:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33716 Wed 12 Dec 2018 14:03:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30921 Wed 11 Apr 2018 14:06:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22634 Wed 11 Apr 2018 13:56:06 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29476 50% ‘green’ items, as assessed via standardised menu audits undertaken by trained dietitians. For each primary outcome, between-group differences were assessed using Fisher’s exact test under an intention to treat approach. Results: There was insufficient evidence to conclude the intervention had a positive impact on the proportion of intervention schools with no ‘red’ or ‘banned’ items on their menu (RR = 2.8; 95% CI: 0.9 to 8.9; p = 0.0895), or on the proportion of intervention schools with more than 50% ‘green’ items (RR = 1.5; 95% CI: 0.7 to 3.2; p = 0.2568). These findings remained non-significant in the multiple imputation analyses. Intervention schools were significantly more likely to have a lower percentage of ‘red’ items (p-value: 0.007) and a higher percentage of ‘green’ items on the menu (p-value: 0.014). This remained statistically significant in the multiple imputation analyses for ‘red items’ (p-value: 0.0081) but not for ‘green’ items (p-value: 0.0910). Conclusions: While there was insufficient statistical evidence to suggest that this multicomponent audit and feedback intervention was effective in improving primary schools’ compliance with a healthy canteen policy, the intervention demonstrated some positive impact in reducing the availability of ‘red’ items on the menu.]]> Wed 11 Apr 2018 11:32:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16808 Wed 11 Apr 2018 10:57:45 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22672 Wed 11 Apr 2018 10:11:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13926 Wed 11 Apr 2018 09:52:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30654 Wed 11 Apr 2018 09:39:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35488 Wed 10 Nov 2021 15:13:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35771 Wed 09 Mar 2022 15:58:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34209 Wed 09 Feb 2022 15:53:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34432 Wed 06 Apr 2022 14:03:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43939 Wed 05 Oct 2022 12:51:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34208 −8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality.]]> Wed 04 Sep 2019 09:48:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33860 Wed 04 Sep 2019 09:48:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24172 Wed 04 Dec 2019 11:31:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52879 Tue 31 Oct 2023 10:46:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52882 Tue 31 Oct 2023 10:45:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54057 Tue 30 Jan 2024 13:56:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41826 Tue 28 Mar 2023 11:27:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47636 Tue 24 Jan 2023 14:30:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38855 Tue 22 Feb 2022 15:26:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44624 P<.0001; with adjustment for infant sex and maternal body mass index). Indigenous mean birthweight percentile was 4.2 units lower (P<.0001). Adjustment for maternal age, smoking, body mass index, and infant sex reduced the difference in birthweight/percentiles to nonsignificance (12 g; P=.07). Conclusion: Disparities exist between indigenous and non-indigenous Australian infants for birthweight, birthweight percentile, and adverse outcome rates. Adjustment for smoking and maternal age removed any significant difference in birthweights and birthweight percentiles for indigenous infants. Our data indicate that birthweight percentiles should not be adjusted for indigenous ethnicity because this normalizes disadvantage; because White and indigenous Australians have diverged for approximately 50,000 years, it is likely that the same conclusions apply to other ethnic groups. The disparities in birthweight percentiles that are associated with smoking will likely perpetuate indigenous disadvantage into the future because low birthweight is linked to the development of chronic noncommunicable disease and poorer educational attainment; similar problems may affect other indigenous populations.]]> Tue 18 Oct 2022 11:09:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46351 n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. Results: Increased gene expression of ACE2 was associated with older age (P = 0.03) and male sex (P = 0.03), but not with pack-years smoked. When we compared gene expression between adults with asthma, COPD and healthy controls, mean ACE2 expression was lower in asthma patients (P = 0.01). Gene expression of furin, a protease that facilitates viral endocytosis, was also lower in patients with asthma (P = 0.02), while ADAM-17, a disintegrin that cleaves ACE2 from the surface, was increased (P = 0.02). ACE2 protein expression was also reduced in endobronchial biopsies from asthma patients. Conclusion: Increased ACE2 expression occurs in older people and males. Asthma patients have reduced expression. Altered ACE2 expression in the lower airway may be an important factor in virus tropism and may in part explain susceptibility factors and why asthma patients are not over-represented in those with COVID-19 complications.]]> Tue 15 Nov 2022 15:15:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48826 Tue 09 May 2023 10:38:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50517 Tue 08 Aug 2023 14:23:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37736 Tue 08 Aug 2023 10:33:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36175 Tue 07 Apr 2020 15:20:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29246 Tue 05 Jul 2022 14:14:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29230 Tue 05 Jul 2022 14:13:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33398 Tue 03 Sep 2019 18:19:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34984 Tue 03 Sep 2019 18:01:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34050 Thu 28 Oct 2021 13:03:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34938 Thu 28 Oct 2021 12:36:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45371 Thu 27 Oct 2022 15:11:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37872 Thu 27 May 2021 15:52:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45682 Thu 25 Jan 2024 14:40:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46513 Thu 24 Nov 2022 15:43:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35094 Thu 20 Jun 2019 15:56:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39156 2 (1, n = 19; 19.0, p = 0.392)). Inter-rater agreement for the modified 81-item Home-CookERI™ was almost-perfect to perfect for 46% of kitchen items (n = 37 items, κ = 0.81–1), moderate to substantial for 28% (n = 23, κ = 0.51–0.8), slight to fair for 15% (n = 12, κ = 0.01–0.5), and chance or worse for 11% of items (n = 9, κ ≤ 0.0). Home-CookERITM was further optimized by reduction to a 77-item version, which is now available to researchers. Conclusion: Home-CookERI™ is a comprehensive tool for quantifying Australian household cooking environments. It has excellent face and content validity and moderate to perfect inter-rater agreement for almost three-quarters of included kitchen items. To expand Home-CookERI™ applications, a home occupant self-completion version is planned for validation.]]> Thu 19 May 2022 16:29:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38648 Thu 18 Aug 2022 14:52:06 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42106 Thu 18 Aug 2022 13:32:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37057 Thu 17 Feb 2022 09:29:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36683 Thu 17 Feb 2022 09:29:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37954 Thu 16 Nov 2023 12:21:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38626 Thu 09 Dec 2021 14:48:14 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27029 Thu 09 Dec 2021 11:05:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47847 Thu 02 Feb 2023 16:26:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41461 TP53 vary depending on the subtype, such that ER-negative tumours have a high rate, and in ER-positive tumours they are less common. Previous studies have implicated the intronic polymorphism in TP53 (rs17878362; or PIN3) with an increased risk of developing breast cancer, although little has been discerned on its prevalence in different subtypes. In this study, we investigated the prevalence of the PIN3 genotype in the blood of cohorts with ER-positive and the ER-negative subtype TNBC, and assessed its association with outcome. Methods: We genotyped 656 TNBC and 648 ER-positive breast cancer patients, along with 436 controls, and compared the prevalence of polymorphism rs17878362 in these cohorts. Results: We found there to be no differences in the prevalence of the PIN3 genotype between the ER-positive and TNBC cohorts. Furthermore, no statistically significant difference was observed in the outcome of patients in either cohort with respect to their PIN3 genotype. Conclusions: Taken together, our results do not support an association of the PIN3 genotype with increased breast cancer risk, either in ER-positive or ER-negative patients.]]> Thu 01 Sep 2022 11:19:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46836 Thu 01 Dec 2022 15:01:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49208 Sun 07 May 2023 09:30:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12709 Sat 24 Mar 2018 08:16:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20953 Sat 24 Mar 2018 08:06:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17327 Sat 24 Mar 2018 08:01:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17373 Sat 24 Mar 2018 08:01:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19672 Sat 24 Mar 2018 08:01:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18447 50 years, showing a rapid increase in the rates of CIS from 2001. * There was an 11% (P = 0.04) and 14% (P = 0.02) annual increase in incidence of CIS in men and women and these rates increased with age. Conclusions * National data (AIHW) substantially underestimate the incidence of CIS in the Australian population. * Patient level data suggest CIS rates are rapidly increasing in Australia despite high treatment rates. * Closer surveillance and awareness of these high rates warrants further study and we recommend that CIS be considered a reportable disease.]]> Sat 24 Mar 2018 07:59:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31120 Sat 24 Mar 2018 07:41:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29906 P=0.42) and vegetable (P=0.17) intakes between HCFV and LCFV groups. Dietary alpha carotene, beta carotene, lutein, and beta cryptoxanthin intakes were significantly different between the two groups (P<0.01). Following HCFV there was a significantly greater increase in skin yellowness (b*) in both sun-exposed (P<0.001) and unexposed areas, (P<0.001), with no change in skin lightness (L*) or redness (a*). Significantly higher plasma alpha carotene (P=0.004), beta carotene (P=0.001), and lutein (P=0.028) concentrations were found following the HCFV intervention. Skin yellowness correlated with alpha carotene and beta carotene. Conclusions: Skin yellowness (b*) and fasting plasma carotenoid concentrations were significantly higher following HCFV than LCFV over 4 weeks.]]> Sat 24 Mar 2018 07:40:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30267 n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρˆ| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.]]> Sat 24 Mar 2018 07:33:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29806 p<0.002; 0.05/25), with a nominal p-value considered as suggestive evidence. For SNPs with evidence of replication, effects on the expression levels of nearby genes in lung tissue were tested in 1,111 lung samples (Lung eQTL consortium), with further functional investigation performed using public epigenomic profiling data (ENCODE). Results: NCOR2-rs12708369 showed strong replication in children (p = 0.0002), with replication unavailable in adults due to low imputation quality. This intronic variant is in a strong transcriptional enhancer element in lung fibroblasts, but its eQTL effects could not be tested due to low imputation quality in the eQTL dataset. SERPINE2-rs6754561 replicated at nominal level in both adults (p = 0.036) and children (p = 0.045), while WNT16-rs2707469 replicated at nominal level only in adults (p = 0.026). The eQTL analyses showed association of WNT16-rs2707469 with expression levels of the nearby gene CPED1.We found no statistically significant eQTL effects for SERPINE2-rs6754561. Conclusions: We have identified a new gene, NCOR2, in the retinoic acid signalling pathway pointing to a role of vitamin A metabolism in the regulation of FVC. Our findings also support SERPINE2, a COPD gene with weak previous evidence of association with FVC, and suggest WNT16 as a further promising candidate.]]> Sat 24 Mar 2018 07:30:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25923 Sat 24 Mar 2018 07:27:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27564 Sat 24 Mar 2018 07:23:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24437 Sat 24 Mar 2018 07:17:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23722 Sat 24 Mar 2018 07:16:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22834 Sat 24 Mar 2018 07:16:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24253 Sat 24 Mar 2018 07:15:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21967 Sat 24 Mar 2018 07:14:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50640 Mon 31 Jul 2023 16:34:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33273 2+ release, leading to sarcoplasmic reticulum Ca²⁺ depletion, reduced cardiac function, and providing cell protection against ischemia-reperfusion injury. Anesthetic activation of ryanodine receptor 2 is poorly defined, leaving aspects of the protective mechanism uncertain. Methods: Ryanodine receptor 2 from the sheep heart was incorporated into artificial lipid bilayers, and their gating properties were measured in response to five halogenated anesthetics. Results: Each anesthetic rapidly and reversibly activated ryanodine receptor 2, but only from the cytoplasmic side. Relative activation levels were as follows: halothane (approximately 4-fold; n = 8), desflurane and enflurane (approximately 3-fold,n = 9), and isoflurane and sevoflurane (approximately 1.5-fold, n = 7, 10). Half-activating concentrations (Kₐ) were in the range 1.3 to 2.1 mM (1.4 to 2.6 minimum alveolar concentration [MAC]) with the exception of isoflurane (5.3 mM, 6.6 minimum alveolar concentration). Dantrolene (10 µM with 100 nM calmodulin) inhibited ryanodine receptor 2 by 40% but did not alter the Kₐ for halothane activation. Halothane potentiated luminal and cytoplasmic Ca²⁺ activation of ryanodine receptor 2 but had no effect on Mg²⁺ inhibition. Halothane activated ryanodine receptor 2 in the absence and presence (2 mM) of adenosine triphosphate (ATP). Adenosine, a competitive antagonist to ATP activation of ryanodine receptor 2, did not antagonize halothane activation in the absence of ATP. Conclusions: At clinical concentrations (1 MAC), halothane desflurane and enflurane activated ryanodine receptor 2, whereas isoflurane and sevoflurane were ineffective. Dantrolene inhibition of ryanodine receptor 2 substantially negated the activating effects of anesthetics. Halothane acted independently of the adenine nucleotide-binding site on ryanodine receptor 2. The previously observed adenosine antagonism of halothane activation of sarcoplasmic reticulum Ca²⁺ release was due to competition between adenosine and ATP, rather than between halothane and ATP.]]> Mon 24 Sep 2018 13:26:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44738 Mon 24 Oct 2022 08:35:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50955 Mon 14 Aug 2023 14:36:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46970 Mon 12 Dec 2022 16:19:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54761 Mon 11 Mar 2024 15:00:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33670 Mon 01 Jul 2019 09:50:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35697 Fri 25 Oct 2019 12:59:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38007 Fri 23 Jul 2021 15:12:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50835 Fri 18 Aug 2023 10:27:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39651 Fri 17 Jun 2022 13:19:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49387 60 years old and accepted onto the National Organ Matching Service. This RKT Group was divided into donor renal cancers ≤30 mm and >30–≤50 mm. Adverse event profiles for RKT recipients were compared with 22 standard live donor recipients using logistic regression analyses. Recipient and transplant survivals for RKT were compared with 2050 controls from Australian New Zealand Dialysis Transplant Registry using Cox regression models. To increase statistical power for survival analyses, data from 25 RKT recipients from Princess Alexandra Hospital, Brisbane were added, thus creating 48 RKT recipients.Results: There were no significant differences in mortality, transplant failure nor AEs between the 2 cancer Groups. RKT increased the risks of Adverse event profiles (odds ratio: 6.48 [2.92–15.44]; P < 0.001). RKT reduced mortality risk by 30% (hazard ratio [HR]: 0.70 [0.36–1.07]; P = 0.299) compared with those continuing on the transplant list who may or may not be transplanted. RKT significantly reduced mortality risk for those remaining on dialysis (HR: 2.86 [1.43–5.72]; P = 0.003). Transplant survival for RKT was reduced compared with control deceased donor (HR: 0.42 [0.21–0.83]; P = 0.013) and live donor transplants (HR: 0.33 [0.02–0.86]; P =0.023).Conclusions:The use of larger carefully selected cancer-resected kidneys for transplantation appears safe and effective. RKT confers a possible survival advantage compared with waiting for transplantation, an increased survival compared with those remaining on dialysis but reduced transplant survival.]]> Fri 12 May 2023 14:27:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32492 Fri 08 Jun 2018 14:22:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38253 Fri 03 Sep 2021 14:46:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32540 Fri 03 Dec 2021 10:32:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51357 Fri 01 Sep 2023 13:45:52 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51351 Fri 01 Sep 2023 13:36:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34474 Fri 01 Apr 2022 09:29:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36967 28 weeks) and kidney function in infants, <2.5 years of age, from the Gomeroi gaaynggal cohort. Pre‐pregnancy body mass index (BMI) was recorded at the first prenatal visit and maternal adiposity indicators (percent body fat and visceral fat area) measured at >28 weeks gestation by bioelectrical impedance analysis. Fetal kidney structure was assessed by ultrasound. Renal function indicators (urinary albumin:creatinine and protein:creatinine) were measured in infants from a spot urine collection from nappies. Multiple linear regression and multi‐level mixed effects linear regression models with clustering were used to account for repeated measures of urine. 147 mother–child pairs were examined. Estimated fetal weight (EFW), but not fetal kidney size, was positively associated with maternal adiposity and pre‐pregnancy BMI. When adjusted for smoking, combined kidney volume relative to EFW was negatively associated with maternal percentage body fat. Infant kidney function was not influenced by maternal adiposity and pre‐pregnancy BMI (n = 84 observations). Current findings show that Indigenous babies born to obese mothers have reduced kidney size relative to EFW. We suggest that these babies are experiencing a degree of glomerular hyperfiltration in utero, and therefore are at risk of developing CKD in later life, especially if their propensity for obesity is maintained. Although no impact on renal function was observed at <2.5 years of age, long‐term follow‐up of offspring is required to evaluate potential later life impacts.]]> Fri 01 Apr 2022 09:27:39 AEDT ]]>